個人簡介

李凱凱，中共黨員，1987年生，籍貫河南魯山。2013年博士畢業于中山大學生命科學學院，2011年起在香港中文大學中醫中藥研究所及生物醫學學院從事中醫中藥和營養健康相關領域的研究工作，2016年入職77779193永利官网。目前主要從事食品組分安全評價和營養健康功能研究，包括果蔬、傳統藥食同源原料和食物源營養組分的功能活性的挖掘、評價及安全評估以及相關産品的開發。目前主持國家自然科學基金、湖北省自然科學基金及國際合作項目等科研項目20餘項，申請專利9項，授權2項，發表論文30餘篇。

教育經曆

2008-9至2013-7,中山大學,生态學, 博士
2004-9至2008-7, 河南師範大學, 生物技術, 學士

工作經曆

2016.7-至今 77779193永利官网食品科技學院
2013.7-2016.6 香港中文大學生物與醫學學院中醫中藥研究所訪問學者
2011.12-2013.6 香港中文大學研究助理

研究領域

新型功能組分挖掘及精準營養
藥食同源類原料食品化加工新策略

科研項目

1、EGT基于Nrf-2-CD36通路改善高脂飲食誘導小膠質細胞吞噬功能受損的機制研究國家自然科學基金面上項目 2024-2027
2、流體型吞咽障礙人群營養食品研發湖北省重點研發項目（子課題）2022-2024
3、武陵山區生态綠茶特征品質智能分析與标準研究國家重點研發項目（子課題）2023-2026
4、植物基替代蛋白肉綠色制造關鍵技術聯合攻關，77779193永利官网深圳營養與健康研究院培育項目（聯合主持）2022-2023
5、魚腥草配方制劑藥代動力學研究國際合作項目（企業合作）2022-2024
6、消炎止痛貼藥效學研究國際合作項目（企業合作）2022-2024
7、納米包埋中藥藥效評價及藥代動力學分析國際合作項目（企業合作）2019-2021
8、不同人群的健康數據庫和營養需求數據庫的搭建及建模企業委托2022-2023
9、藥物改善認知實驗研究企業委托 2023-2024
10、原花青素抑制金黃色葡萄球菌生物被膜形成的分子機理及與群體感應調控的關聯機制國家自然科學基金 2018-2020
11、柿高酰基原花青素低聚體的制備及抗氧化和抗輻射活性研究湖北省自然科學基金2017-209
12、不同機體對環境壓力誘導的焦慮響應及飲食幹預的改善作用和潛在機制校自主創新基金 2020-2022
13、氧化應激及原花青素幹預對3T3-L1原脂肪細胞分化的影響和減肥作用研究校自主創新基金 2016-2019

成果獎勵

一、主要論文目錄

1、Yu Ying, Peng Jinming, JiaYangyang,Guan Qingyun, Xiao Gengsheng, Li Chunmei, Shen Shanshan*, Li Kaikai*. Chemical characterization-function relationship of pectins from persimmon fruit within different ripeness. Food Chemistry, 2024, 435, 137645.
2、Zhang Jiaming, Jia Yangyang，Wu Wenjin，Zhang Yingying，Wei Xuetuan, Li Chunmei，Li Kaikai. Influence of hemin on structure and emulsifying properties of soybean protein isolate, Food chemistry, 2023, 421, 136183.
3、Chen Ping, Li Xiaofang, Yu Ying, Zhang Jiaming, Zhang Yingying, Li Chunmei, Li Jing, Li Kaikai. Administration time and dietary patterns modified the effect of inulin on CUMS-induced anxiety and Depression. Molecular Nutrition & Food Research, 2023, 17653992.
4、Li Xiaofang, Chen ping, Zhang Yinging, Zhang Jiaming, Shen Shanshan, Li Kaikai. Intervention time modified the effect of inulin on high-fat diet-induced obesity and gut microbial disorders. Food Frontiers 2023, 00, 1-124.
5、Yang Zenan, Li Xiaofang, Li Dianwei, Wang Cheng, Ren Jingnan, Li Kaikai*, Chen Hao*. Chemical constitutes and anti-obesity potential of seedlings of purple-leafed rice in high-fat diet induced obese mice. Food & Function, 2022, 13, 12426.
6、Wang, Ruifeng, Zhang, Yajie, Jia Yangyang, Zhang, Mengying, Li, Kaikai. Persimmon oligomeric proanthocyanidins exerts antibacterial activity through damaging the cell membrane and disrupting energy metabolism of Staphylococcus aureus. ACS Food Science & Technology, 2021, 1, 1, 35-44.
7、Shi, Xin, Shang, Feifei., Zhang, Yangjia, Wang, Ruifeng, Jia, Yangang, Li, KaiKai*. Persimmon oligomeric proanthocyanidins alleviates UV-B induced skin damage by regulating oxidative stress and inflammatory responses. Free Radical Research, 2020, 54(10), 765-776.
8、Peng, Jinming, Jia, Yan, Hu, Tianyong, Du, Jing, Wang, Yue, Cheng, Baohui, Li, Kaikai*. GC-(4 -> 8)-GCG, A Proanthocyanidin Dimer from Camellia ptilophylla, Modulates Obesity and Adipose Tissue Inflammation in High-Fat Diet Induced Obese Mice, Molecular Nutrition & Food Research, 2019, 63(11), 1900082.
9、Li, Kaikai, Zhang, Mengying, Chen, Haoze, Peng, Jinming, Jiang, Fan, Shi, Xin, Bai, Yilin, Jian, Min, Jia, Yangyang. Anthocyanins from black peanut skin protect against UV-B induced keratinocyte cell and skin oxidative damage through activating Nrf 2 signaling , Food & Function, 2019, 10(10), 6815-6828.
10、Peng, Jinming, Hu, Tianyong, Du, Jing, Li, Jin, Zhu, Kerui, Cheng, Baohui, Li, Kaikai, Shepherd’s Purse Polyphenols Exert Its Anti-Inflammatory and Antioxidative Effects Associated with Suppressing MAPK and NF-κB Pathways and Heme Oxygenase-1 Activation. Oxidative Medicine and Cellular Longevity 2019.
11、Li Kaikai, Yao Fen, Du Jing, Deng Xiangyi, Li Chunmei. Persimmon Tannin Decreased the Glycemic Response through Decreasing the Digestibility of Starch and Inhibiting alpha-Amylase, alpha-Glucosidase, and Intestinal Glucose Uptake, Journal of Agricultural and Food Chemistry, 2018, 66(7), 1629-1637.
12、Peng, Jinming, Jia, Yan, Du, Xia, Wang, Yue, Yang, Zimu, Li, Kaikai*; Study of physicochemical stability of anthocyanin extracts from black peanut skin and their digestion enzyme and adipogenesis inhibitory activities, LWT-Food Science and Technology, 2019, 107, 107-116.
13、Li Kai Kai, Shen Shan Shan, Deng Xiangyi, Shiu Hoi Ting, Siu Wing Sum, Leung Ping Chung, Ko Chun Hay*, Cheng Bao Hui*. Dihydrofisetin exerts its anti-inflammatory effects associated with suppressing ERK/p38 MAPK and Heme Oxygenase-1 activation in lipopolysaccharide-stimulated RAW 264.7 macrophages and carrageenan induced mice paw edema. International Immunopharmacology, 2018, 54:366-374.
14、Torkun Mamet, Yao Fen, Li Kai-kai *, Li Chun-mei *. Persimmon tannins enhance the gel properties of high and low methoxyl pectin, LWT- Food Science and Technology, 2017, 86, 594-602.
15、Li Kaikai, Peng Jinming, Zhu Wei, Cheng Baohui, Li Chunmei, Gallocatechin gallate (GCG) inhibits 3T3-L1 differentiation and lipopolysaccharide induced inflammation through MAPK and NF-κB signaling, Journal of Functional Foods, 2017, 30(3), 159-167.
16、Li Kaikai, Zhou Xuelin, Wong HingLok, Ng ChunFai, Fu WeiMing, Leung PingChung, Peng Guiyuan, Ko Chun Hay, In vivo and in vitro anti-inflammatory effects of Zao-Jiao-Ci (the spine of Gleditsia sinensis Lam.) aqueous extract and its mechanisms of action, Journal of Ethnopharmacology, 2016, 192, 192-200.
17、Li Kaikai, Zhou Xuelin, Liu Cheuklun, Yang Xiaorong, Han Xiaoqiang, Shi Xianggang, Song Xiaohong, Ye Chuangxing, Ko Chunhay, Preparative separation of gallocatechin gallate from Camellia ptilophylla using macroporous resins followed by sephadex LH-20 column, Journal of Chromatography B, 2016, 1011, 6-13.
18、Li Kaikai, Wong Hing Lok, Hu Tianyong, Zhang Cheng, Han Xiaoqiang, Ye Chuangxing, Leung PingChung, Cheng BaoHui, Ko ChunHay, Impacts of Camellia kucha and its main chemical components on the lipid accumulation in 3T3-L1 adipocytes. International Journal of Food Science and Technology, 2016, 51, 1546-2555.
19、Li KaiKai, Liu ChuekLun, Shiu HoiTing, Wong HingLok, Siu WingSum, Zhang Cheng, Han XiaoQiang, Ye ChuangXing, Leung PingChung, Ko ChunHay, Cocoa tea (Camellia ptilophylla) water extract inhibits adipocyte differentiation in mouse 3T3-L1 preadipocytes. Scientific Reports, 2016, 6, 20172.
20、Li Kaikai, Zhou Xuelin, Yang Xiaorong, Shi Xianggang, Song Xiaohong, Ye Chuangxing, Ko Chun Hay. Subacute oral toxicity of cocoa tea (Camellia ptilophylla) water extract in SD rats, International Journal of Food Science and Technology, 2015, 50(11), 2391-2401.
21、Li Kaikai, Liu Cheuklun, Jacqueline Chorwing Tam, Hinfai Kwok, Lau Chingpo, Leung Pingchung, Ko Chunhay, Ye Chuangxing, In vitro and in vivo mechanistic study of a novel proanthocyanidin, GC-(4→8)-GCG from cocoa tea (Camellia ptilophylla) in antiangiogenesis，Journal of Nutritional Biochemistry, 2014, 25(3), 319-328.
22、王玥, 楊明美, 李夢麗, 楊子沐, 李凱凱. 柿子乳酸菌發酵飲料的加工工藝研究, 中國食品學報, 2020, 20(7)：109-125

二、主要專利

1、一種高益生活性的柿果膠、軟糖及其制備方法和應用 CN114982940B
2、一種高聚原花青素的增溶方法及其制得的複合物和應用CN112655873A

師資力量